Job Openings, Master-, Bachelor- and HiWi positions
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- Last Updated on Friday, 22 September 2017 11:18
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Bachelor- und Masterarbeiten (in German)
Thema: Myofibrillären Myopathien.
Dabei handelt es sich um eine Gruppe von sporadischen und erblichen Krankheiten der Skelett -und Herzmuskulatur, die zu schweren körperlichen Behinderungen und vorzeitigem Tod führen. Die Arbeiten werden in enger Kollaboration mit klinischen Partnern (Uni-Klinik, Erlangen) durchgeführt.
Notwendige Qualifikation: Bachelor in ILS, Biologie oder Biochemie.
Wünschenswerte Qualifikation: Grundkenntnisse in MATLAB, Konfokalmikroskopie und Zellkultur. Kenntnisse in computergestützter Bildgebung und Bildauswertung sind vorteilhaft, aber nicht Bedingung.
Bemerkungen: Die Stelle soll zum Master (M.Sc.) der Bewerberin/des Bewerbers führen. Aufgabe des Masterstudenten(in) ist es, mechanische Messungen an skeletalen Myoblasten und Myotuben von zwei der häufigsten humanpathogenen Mutationen (R155C VCP und W2710X filamin C) mittels Traktionsmikroskopie, Magnetbead-Mikrorheologie und einem Zellstretcher in Kombination mit Konfokalmikroskopie mit hoher zeitlicher und räumlicher Auflösung durchzuführen.
Für Auskünfte kontaktieren Sie bitte Prof. Wolfgang Goldmann, PhD, Biophysics Group der FAU, Center for Medical Physics und Technology, Henkestr 91, 91052 Erlangen. Phone: (+49) (0)9131-85-25605 fax: (+49) (0)9131-85-25601 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Dilated cardiomyopathy caused by mutations in A-type lamins.
Dilated cardiomyopathy is one of the leading causes of heart failure in Europe. Despite of the conventional medical care, there is no definitive and satisfactory treatment for the progressive cardiac dilatation and loss of contractility in LMNA cardiomyopathy short of heart transplantation. LMNA gene encodes nuclear A-type lamins, which are the main constituents of the nuclear lamina. To explain how mutations in proteins of the nuclear envelope can cause a disease of the heart, it has been proposed that nuclear envelope abnormalities bring about cellular fragility and a decrease in the mechanical resistance to stress, which could partially explain the cardiac muscle disease, considering that the heart muscle is constantly subjected to mechanical force.
In preliminary work, we showed that there is an abnormal activation of stress-activated ERK1/2 signaling in hearts that carry LMNA mutations. Administration of drugs inhibiting ERK1/2 signaling improves cardiac ejection fraction in mice and blunts further increase in left ventricular dilatation. These studies clearly show that the abnormal ERK1/2 activation is involved in the pathophysiology of LMNA dilated cardiomyopathy.
It is therefore important to further our knowledge on the pathophysiology of cardiomyopathies and to determine the influence of external/internal stress in order to unveil molecular/cellular mechanisms to target future therapeutic approaches.
Required qualifications: Bachelor in ILS, biology or biochemistry.
Desirable qualifications: Basic knowledge of MATLAB, confocal microscopy and cell culture. Knowledge in computer-aided imaging and image analysis are advantageous, but not essential.
Name | Beginn | Thema | Betreuer | |
David Böhringer | This email address is being protected from spambots. You need JavaScript enabled to view it. | März 2015 | Spheroide: Traktionsmessungen | Christoph Mark |
Annemarie Pfnür |
aThis email address is being protected from spambots. You need JavaScript enabled to view it.
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Feb 2015 | Spheroide: Vergleich unterschiedlicher Tumor-Zell-Linien (wie in Janina's 2D-Studie) | Christoph und Ingo |
Christian Heidorn | This email address is being protected from spambots. You need JavaScript enabled to view it. | April 2015 | high speed camera system for life cell imaging | Sebastian, Janina |
Monika Spermann | This email address is being protected from spambots. You need JavaScript enabled to view it. | mitte April 2015 | Zusammenhang zwischen Zellsteifheit und 3-D Migration bei Tumorzellen | Janina |
Sabrine Munz undCorinna Munz | cThis email address is being protected from spambots. You need JavaScript enabled to view it. | Ende Feb 2015 | Einfluss von Kollagendichte, Steifheit und adhäsive Funktionalisierung auf das Invasionverhalten bei verschiedenen Zellarten Einfluss der Zelldichte | Christoph und Ingo |
Sarah Hoepffner |
sThis email address is being protected from spambots. You need JavaScript enabled to view it.
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März 2015 | Mechanismen der Tumorzell-Invasion (Einzelzellen, Organoid, Einfluss der Matrix, Einfluss von Zelleigenschaften wie Adhäsivität, Kontraktilität etc.) | Christoph, Ingo, Ben |
Elena Schindelek |
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2. März 2015 | dynamisches Zell-Tracking (Bayes Fingerprinting): Einfluss der Tiefe, Einfluss der Zelldichte, Einfluss der Matrix (Porosität, Stiffness etc) | Ben etc |
Moritz Brehm |
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20. März | Python for cell tracking in a 3D collagen matrix: correlation between cell migration and local geometry | Richard |
Jonas Auernheimer |
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März März2015
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Spheroide und Vinkulin2D Lamellipodium bei VinkulinChorion Allantoic Membrane Assay mit vinkulin-defizienten Zellen |
Ingo
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Delf Kah | This email address is being protected from spambots. You need JavaScript enabled to view it. | 2. März | Effekt unterschiedlicher Polymerisations-Bedingungen auf die Kollagen-Struktur | Chris, Claus |
Alexander Winterl |
This email address is being protected from spambots. You need JavaScript enabled to view it.
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2. März | Random Walks und Probabilistic Programming | Chris, Claus |
Nina Bauer, Master | This email address is being protected from spambots. You need JavaScript enabled to view it. | MA, 13.10.2015 | Bildverarbeitung, Programmierung, Mustererkennung | Chris oder Richard |
Ozlem Özel Bachelor |
This email address is being protected from spambots. You need JavaScript enabled to view it. | BA, 14. Oct 2015 | Vergleich der 3-D Einzelzell-Migration verschiedener Tumorarten | Breff, Ben |
Thorsten Götz |
tThis email address is being protected from spambots. You need JavaScript enabled to view it. | MA, Oct 2015 | T-cell - tumor interactions in 3D | Christoph Mark |
Beate Hartmannsberger |
This email address is being protected from spambots. You need JavaScript enabled to view it. | MA, 15 Oct 2015 | Microconstrictions; carbon black Effekte | Janina |
Samuel Winkler | sThis email address is being protected from spambots. You need JavaScript enabled to view it. | MA, Ende Oct | Viskosität und viskoelastische Eigenschaften von biologischen Proben | Ben |
Jakob Peschel | jThis email address is being protected from spambots. You need JavaScript enabled to view it. | MA, Ende Oct | Huddle-Bildung bei Kaiserpinguinen | Richard |
Andrea Thomaß, | aThis email address is being protected from spambots. You need JavaScript enabled to view it. | MA, Nov 2015 | Tumor-Migration | tba |
Thomas Hirschmann | tThis email address is being protected from spambots. You need JavaScript enabled to view it. | MA, Mar 2016 | Powerlaw-Rheology | Claus |
Julian Übelacker | This email address is being protected from spambots. You need JavaScript enabled to view it. | MA, Mar 2016 | Inference of particle interactions | Claus |
Katharina Tkotz | This email address is being protected from spambots. You need JavaScript enabled to view it. | BA, Mar 2016 | Grid-based Monte-Carlo sim. | Claus |
Julia Kraxner | This email address is being protected from spambots. You need JavaScript enabled to view it. | MA, März 2016 | 3D Muskelstretcher | Ingo |
Claire Amadio | This email address is being protected from spambots. You need JavaScript enabled to view it. | BA, März-Juli 2016 | 3-D Muskelgewebe | Ben |
Alexander Wischnewski |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
BA, 1.5.16 |
Tumor-Invasion |
Ingo |
Fumina Yoshimoto |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Visiting Student
Mai-Juli 2016 |
Myofibrilläre Myopathie | Marina/Wolfgang
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Richard Holfeld |
This email address is being protected from spambots. You need JavaScript enabled to view it. | BA, Okt 2016 - Jan 2017 | 3-D Muskelgewebe | |
Mona Seifert |
This email address is being protected from spambots. You need JavaScript enabled to view it.
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Mitte Oct 2016 |
Bildverarbeitung, Programmierung, Mustererkennung z.B. 3-D Muskelgewebe |
entweder Janina oder Ben oder Ingo oder Richard |
Thomas Halbauer |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Oct 2016 |
Projektpraktikum Physik in der Medizin |
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Michelle Küppers | This email address is being protected from spambots. You need JavaScript enabled to view it. | Oct 2016 | Projektpraktikum Physik in der Medizin | |
Sandra Wiedenmann | This email address is being protected from spambots. You need JavaScript enabled to view it. | Master ILS, ab 17. Oct 2016 | Herzmusdelgewebe | Ingo/Ben |
Katrin Zerbe | This email address is being protected from spambots. You need JavaScript enabled to view it. |
Master Medizintechnik 15. März 2017 |
Mechanik und Adhäsivität von Keratinozyten bei Keratin Mutationen | Marina |
Christopher Dürrbeck |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Master Physik 7. Feb 2017 |
magnetic twisting / tweezing | Ben |
Christina Hillig |
This email address is being protected from spambots. You need JavaScript enabled to view it.
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Master ILS 1. Sept 2017 |
NK Zellen | Christoph |
Anja Amthor |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Bachelor ILS 10.4.2017 |
Mikropartikel | Ben |
Lea Pflüger |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Master Medizintechnik 8.5.2017 |
Mechanische Veränderungen in Nervenzellen bei Aktivierung | Ben |
Marco Fleischer |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Bachelor Medizintechnik 02.05.2017 |
Design einer Inkubationskammer für Mikroskope zur Langzeitmessung von Zellmigration unter Temperaturkontrolle | Ben |
Lucie Plankesteiner |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Bachelor Physik 24.4.2017 |
Optimierung der Kollageneigenschaften und Geometrie zur Bildung von Skelettmuskel-Mikrogeweben | Ben |
Luise Böttcher |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Bachelor ILS 24.4.2017 |
Pinguine | 'Richard |
Lucas Heublein |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
Bachelor ILS 18.4.2017 |
Zelltracking | Ben, Claus, Christoph, Alex |
Michael Hlavatsch |
This email address is being protected from spambots. You need JavaScript enabled to view it. |
ILS Bachelor 18.4.2017 |
Tränen | Ben |